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Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7-9 weeks gestational age, before the onset of fetal hematopoiesis.

The majority of cases, with the exception of 3 vertical growth-phase melanomas, had only slight (1-I-) increased staining (Fig. 1 Dendritic, factor XIIIa positive cells were observed in all tissues studied, but were most numerous in skin and mucosal tissues (gastrointestinal tract, bladder). They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen. [en] Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Our results revealed that the dermis of patch- and plaque-stage KS lesions contains an increased number of factor XIIIa-positive dermal dendrocytes compared with normal dermis and that some of these cells are spindle shaped.

Factor xiiia positive

Factor XIIIa positive control slides are intended for use as positive controls for immunohistochemical (IHC) staining using an anti-Factor XIIIa antibody. Physical form Paraffin embedded tissue section mounted on microscope slide Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition.

Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis.

Conclusion: Factor-XIIIa-positive dendrocytes probably play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction. Background: Lymphocyte-poor graft-versus-host-reaction (GVHR) and toxic epidermal necrolysis (TEN) share some histological resemblance.

Factor XIII a-positive DD may be altered in some genetic disorders affecting the connective tissue structure [15,17,20–26]. There is ample evidence that many, if not all, of these disorders are associated with alterations in the tensile properties of the dermis. In addition, a link between Factor XIII a-positive DD and intratissular mechanical

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Involvement in disease. Factor XIIIa positive cells in granulomatous lymph node lesions Cotton, D.W.K.; Stephenson, T.J.; Hird, P.M. 1990-05-01 00:00:00 Sir: In the recent review (Goudie 1989) of Histological Typing of Thyroid Turnours (Hedinger, Williams & Sobin 1988), attention was drawn to the limited discussion and absence of references in this book as well as in the other volumes in the WHO series. Factor XIIIa positive cells in human skin represent a specific population of bone marrow dermal dendritic cells, distinct from Langerhans cells which share some features common to mononuclear phagocytes. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis.

Factor XIIIa Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-251S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. The immunocytochemical identification and characterization of indigenous dermal dendritic cells (dermal dendrocytes) using a rabbit polyclonal antibody to clotting enzyme factor XIII subunit A (FXIIIa) was carried out on normal and inflamed human cutaneous tissue. Factor XIIIa-positive dendrocytes were plentiful in the uninvolved dermis and were aggregated around the periphery of the tumor nodules. Factor XIIIa is more likely to be negative Tuberous xanthoma: Occurs in areas of pressure Associated with hypercholesterolemia and high LDL Consists of dermal aggregates of foam cells, no Touton cells or inflammatory cells Spitz nevus: Nests of spindle and epithelioid cells within a uniformly hyperplastic epidermis DFSP is diffusely CD34 positive and Factor XIIIa negative, whereas dermatofibromas (and additional fibrohistiocytic tumor types other than DFSP) show the converse of this profile or only limited CD34 reactivity at the advancing edge of the lesion.
Nephritis tubulointerstitial acuta

Staining pattern is highly variable and nonspecific but the following stains may be positive: Factor XIIIa, CD163, CD10. Factor XIIIa is usually negative in DFSP. CD68 may highlight histiocytic cells (Patterson: Weedon's Skin Pathology, 5th Edition, 2020) FXIIIa positive cells in human skin represent a specific population of bone-marrow dermal dendritic cells, distinct from Langerhans cells, that share some features common to mononuc-lear phagocytes (monocyte/macrophages). In addition, the detection of HLA-DQ on 48"n of To assess the use of anti-CD34 and anti-factor-XIIIa antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs.

In addition, the detection of HLA-DQ on 48"n of To assess the use of anti-CD34 and anti-factor-XIIIa antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs. A significant population of dendritic and spindle cells was reactive with anti-factor-XIIIa in 90% of DFs. In DFSP, most cases had very few or no reactive tostatin-positive cells are speci¢cally involved in the healing process of psoriasis. The reduction of the factor XIIIa-posi-tive cells was associated with the healing process as a whole, but showed no relation to either treatment.Key words: dendri-tic cells; epidermal thickness; immunohistochemistry; psoriasis.
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FXIIIa positive cells in human skin represent a specific population of bone-marrow dermal dendritic cells, distinct from Langerhans cells, that share some features common to mononuc-lear phagocytes (monocyte/macrophages). In addition, the detection of HLA-DQ on 48"n of

av K Junkunlo · 2017 — tion to Drosophila, the freshwater crayfish also serves as a good model Then, TGase, a homologue for clotting factor XIIIa mediates the cross- rise to a clinical presentation similar to DVT or PE, resulting in a false positive diagnosis. 99mTc-NC100668 is a substrate for factor XIIIa and as a potential #ISTH2020 #FXIII #FactorXIII #FXIIIa #TECHNOFLUOR #CEVERON_s100.

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Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4.

XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency. Immunohistochemical positive for Factor XIIIa.