(A) Chemical structure of salinomycin. (B) MTT dose‑response curves in JIMT‑1 cells for salinomycin without modification. (C)MTT dose‑response curves in MCF‑7 cells for salinomycin without modification. (D)Purity characterization by high performance‑liquid chromatography and mass spectroscopy for salinomycin without modification. IC

This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. More help available here. EC / List no.: 258-290-1. CAS no.: 53003-10-4. Mol. formula: C42H70O11

Structure, properties, spectra, suppliers and links for: Salinomycin, 53003-10-4. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture. Salinomycin is used in chicken feed as a coccidiostat. Biosynthesis Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological THE STRUCTURE OF SALINOMYCIN, A NEW MEMBER OF THE POLYETHER ANTIBIOTICS Haruyasu Kinashi, Noboru Stake and Hiroshi Yonehara Institute of Applied Microbiology, The University of Tokyo Shoichi Sato and Yoshihiko Saito Institute for Solid State Physics, The University of Tokyo Tokyo, Japan (Received in Japan 3 October 1973; received in UK for Salinomycin sodium salt.

Salinomycin structure

12 okt. 2016 — in hydraulic structures – interactions between water absorption, Björn Borgström: ”Salinomycin analogs: Mechanistic probes and structure 5 nov. 2013 — Design, Synthesis, and Evaluation of Salinomycin Analogs Towards The FET family of Proteins in Sarcomas – Structure, Cell biology, 29 sep. 2018 — Cell biology studies cells – their physiological properties, structure, the Ämnet Salinomycin som Sofia har använt vid forskningen anses som 7 dec. 2015 — tss | wetland reactor | salinomycin | konczewicki | milk house wastewater server | protein structure prediction | protein structure | brachyspira Domain boundaries of salinomycin synthase module 7 Figure S5. SWISS-MODEL1 ( protein structure homology-models of KR0 domains from polyether reactor | salinomycin | konczewicki | milk house wastewater | cobalt | australis protein structure prediction | protein structure | brachyspira | scop | structure med foderantibiotika (klortetracyklin 50 g per ton, salinomycin 50 g per ton) för att förbättra Uncovering the composition of microbial community structure and ämnen. , Negativa effekter; , Cancer stamceller; , Celldöd; , Perifera neuropatier. Abstrakt.

Characteristics and Structure Definition. Cell membrane (also known as plasma membrane or plasmalemma) is a biological membrane that separates the contents of the cell from the outside environment. Functions. Barrier that protects the contents of the cell from the extracellular environment; Anchors the cytoskeleton and defines cellular shape

Ball-and-stick model, geometric structure and structural . salinomycin och monensin är fortfarande tillåtna men föreslås av Soil compaction processes and their effects on the structure of arable soils and the. Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC).

Bushnell, F. Salinomycin as a drug for targeting human cancer stem cells. Kong, M. This post Cell Here is my blog :: essay structure Ericka. Hi there friends

Salinomycin. Molecular Formula C 42 H 70 O 11; Average mass 750.999 Da; Monoisotopic mass 750.491821 Da; ChemSpider ID 2342058 1973-01-01 Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2016-04-28 2017-02-10 Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis 2017-02-15 Salinomycin. 2 Product Results.

File; File history; File usage on Commons; However, two salinomycin derivatives (salinomycin n-butyl amide and salinomycin 2,2,2-trifluoroethyl ester) were identified that showed increased anti-trypanosomal activity with 50 % growth inhibition values in the mid nanomolar range and minimum inhibitory concentrations of below 1 μM similar to suramin, a drug used in the treatment of sleeping sickness. Salinomycin sodium salt Chemical Structure. CAS NO. 55721-31-8. Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Availability: In stock.
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It is an alkali ion carrier with affinity for cations and preference for K + over other monovalent and divalent cations. 2015-02-06 · Although these two kinases are very similar in sequence and structure, they can often have differential effects on the activation of p38 . Our data in human fibroblasts show that the expression and activation of a constitutively active MKK6 attenuate the effect of salinomycin on p38 and myofibroblast formation (Fig. 8). Sacox® consists of salinomycin sodium (active substance) at concentrations of 120 and 200 g/kg (Sacox® 120 and Sacox® 200), silica dioxide as flowability enhancer and calcium carbonate as structure-forming agent and diluent.

Empirical Formula (Hill Notation): C42H70O11. Molecular Weight: 751.00. CAS Number: 53003-10-4. S4526.
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6 Jan 2020 Product Name: Salinomycin sodium. Product Number: S002. CAS Number: 55721-31-8. Molecular Formula: C42H69NaO11. Molecular Weight:.

Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2016-04-28 2017-02-10 Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis 2017-02-15 Salinomycin.

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2017-03-28 · Salinomycin blocked Wnt signaling and downregulated ZEB1, thereby increasing the sensitivity of MCL cells to the cytotoxic effect of gemcitabine, cytarabine, and doxorubicin. 70 In combination with metformin, salinomycin was able to block TGFβ-induced EMT and inhibit EMT-induced cell migration in the two non-small-cell lung cancer cell lines A549 and HCC4006.